DNA – Risico op weefselbeschadiging

Risico op weefselbeschadiging

Het COL1A1 gen bouwt de belangrijkste collageenketen die de sterkte van ligamenten, pezen en gewrichtscapsules beïnvloedt. Deze sterkte beïnvloedt de mobiliteit van gewrichten zoals schouders, knieën en enkels. Hogere niveaus van dit type collageen zorgen voor beter ondersteunde gewrichten en een verminderd risico op letsel.

Collins M, et al. The COL1A1 gene and acute soft tissue ruptures. Br J Sports Med. 2010. 44(14), 1063-1064.
Gallo RA, et al. Common leg injuries of long-distance runners: anatomical and biomechanical approach. Sports health. 2012. 4(6), 485-495.
Kelly AK. Anterior cruciate ligament injury prevention. Curr Sports Med Rep. 2008. 7(5), 255-262.
Khoschnau S, et al. Type I collagen alpha1 Sp1 polymorphism and the risk of cruciate ligament ruptures or shoulder dislocations.
Am J Sports Med. 2008. 36(12), 2432-2436.
Mandelbaum BR, et al. Effectiveness of a neuromuscular and proprioceptive training program in preventing anterior cruciate ligament injuries in female athletes: 2-year follow-up. Am J Sports Med. 2005. 33(7), 1003-1010.
Mann V, et al. A COL1A1 Sp1 binding site polymorphism predisposes to osteoporotic fracture by affecting bone density and quality. J Clin Invest. 2001. 107(7), 899-907.
Posthumus M, et al. Genetic risk factors for anterior cruciate ligament ruptures: COL1A1 gene variant. Br J Sports Med. 2009. 43(5), 352-356.
Posthumus M, et al. The COL5A1 gene is associated with increased risk of anterior cruciate ligament ruptures in female participants. Am J Sports Med. 2009. 37(11), 2234-2240.
Sallis RE, et al. Comparing sports injuries in men and women. Int J Sports Med. 2001. 22(6), 420-423.
Soligard T, et al. Comprehensive warm-up programme to prevent injuries in young female footballers: cluster randomised controlled trial. BMJ. 2008. 337, a2469.
Wang C, et al. Association of polymorphisms rs1800012 in COL1A1 with sports-related tendon and ligament injuries: a meta-
analysis. Oncotarget. 2017. 8(16), 27627-27634.
Collins M, et al. The COL1A1 gene and acute soft tissue ruptures. Br J Sports Med. 2010. 44(14), 1063-1064.
Khoschnau S, et al. Type I collagen alpha1 Sp1 polymorphism and the risk of cruciate ligament ruptures or shoulder dislocations. Am J Sports Med. 2008. 3 6(12), 2432-2436.
Wang C, et al. Association of polymorphisms rs1800012 in COL1A1 with sports-related tendon and ligament injuries: a meta-
analysis. Oncotarget. 2017. 8(16), 27627-27634.

Risico op weefselbeschadiging

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