Gewicht, eetlust en obesitas
- Informatie over jouw gen
Het FTO-gen is gekoppeld aan lichaamsgrootte, lichaamsvetopslag en obesitas. Dit gen beïnvloedt de eetgewoonten, de voedingsvoorkeuren, de eetlust en het gevoel vol te zijn in het controlecentrum van de hersenen (de hypothalamus). Het FTO-gen is ook geassocieerd aan je kans op overgewicht.
- Bronnen
- Frayling TM, Timpson NJ, Weedon MN, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007; 316(5826): 889-94.
- Kara E, O’Daly OG, Choudhury AI, et al. A link between FTO, ghrelin, and impaired brain food-cue responsivity. J Clin Invest 2013; 123 (8): 3539-51
- Tovar A, Emond JA, Hennessy E, Gilbert-Diamond D. An FTO Gene Variant Moderates the Association between Parental Restriction and Child BMI. PLoS One 2016; 11(5): e0155521.
- Livingstone KM, Celis-Morales C, Papandonatos GD, et al. FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials. BMJ 2016; 354: i4707.
- Zhang X, Qi Q, Zhang C, et al. FTO genotype and 2-year change in body composition and fat distribution in response to weight- loss diets: the POUNDS LOST Trial. Diabetes 2012; 61(11): 3005-11.
- Wycherley TP, Moran LJ, Clifton PM, Noakes M, Brinkworth GD. Effects of energy-restricted high-protein, low-fat compared with standard-protein, low-fat diets: a meta-analysis of randomized controlled trials.Am J Clin Nutr 2012; 96(6):1281-98.
- Andreasen CH, Stender-Petersen KL, Mogensen MS, et al. Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation. Diabetes 2008; 57(1): 95-101.
- Kilpelainen TO, Qi L, Brage S, et al. Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med 2011; 8(11): e1001116.
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